The reception of Segundo romance was very positive. Critics highlighted the quality of the production, Luis Miguel's vocal performance, and the careful selection of songs. The album managed to keep the bolero genre's popularity alive, just as its predecessor had done. In fact, the album won a Grammy Award in the category of "best Latin pop album." Several important singles were released from this work. "El día que me quieras" and "La media vuelta" reached the top spot on the Billboard Hot Latin Songs chart in the United States. Other songs like "Todo y nada" and "Delirio" also had a good reception on the same chart.
This album was a great commercial success, selling over 4 million copies in 1995 alone and achieving multiple platinum certifications in countries across Latin America, the United States, and Spain. It positioned itself as one of the best-selling Latin albums of the year and, by the 1990s, was the most successful Latin album by a male artist. The particularity of Segundo romance lies in its ability to reinterpret classics while maintaining the essence of Latin ballads, and its impact on the continuation of Luis Miguel's legacy in this musical style.