Of the fifteen songs, three stand out for their immediate impact: «Here Comes Your Man», a single that climbed the Modern Rock Tracks chart in the United States; «Monkey Gone to Heaven», with its environmental critique; and «Debaser», where the band fused chaos and melody. The specialized press received the album with varied praise: NME called it a work that "makes you jump out of your skin", while Rolling Stone gave it three and a half stars in its first review. By the time Doolittle had been on the market for six months, it had already sold over one hundred thousand copies in the United States.
The recording process was not linear. Black Francis, the band's leader, composed most of the songs during a European tour with Throwing Muses in 1988, and some were even premiered in live sessions for the BBC or on a free EP from Sounds magazine. Norton, who had already worked with the band on the single «Gigantic», spent weeks pre-producing the material, adapting the arrangements to Francis' ever-changing personality. The result was an album that, decades later, remains certified gold in the United States and a benchmark for alternative rock artists.