The album had a lead single that resonated worldwide: "Another Day in Paradise". This song, born from a visit by Collins to Washington D.C. where he witnessed the city's poverty and indifference, is a critical look at the situation of the homeless. The track became a resounding success, reaching number one in the United States for four weeks and achieving high peaks in countries like Finland, Canada, and Germany, in addition to reaching the top 10 in the United Kingdom and Spain. Another cut with an important social message is "Colours", a condemnation of segregation in South Africa during apartheid, which, despite its progressive rock influence close to Genesis and its nearly nine-minute duration, did not have the same commercial impact. Also, "That’s Just the Way It Is" addresses political themes, referring to sectarian differences in Northern Ireland.
Despite this more introspective and social focus, …But Seriously did not completely abandon relationship themes, but it did so from a more mature and reflective perspective. The album was released by Virgin Records and Atlantic Records, and its 1989 release positioned it as one of the best-selling albums of 1990 in the United Kingdom. In 2016, a two-disc remastered version was released that included additional material such as live songs and demos.