One of the most notable moments of 461 Ocean Boulevard is undoubtedly the cover of "I Shot the Sheriff". Originally by Bob Marley, Clapton's rendition became a major hit. The story goes that it was George Terry who suggested he record it, and although Clapton initially hesitated out of respect for the original, he eventually agreed, and the song became a very popular single. Another standout track is "Let It Grow", written by Clapton himself, although its melodic similarity to Led Zeppelin's "Stairway to Heaven" has been noted. The album also includes covers of songs that already resonated with Clapton, such as "Willie and the Hand Jive" and "I Can’t Hold Out".
This work not only signified Clapton's return to active music but was also a commercial success, reaching the top spots on international charts and selling millions of copies. In 2004, a special two-disc edition was released that included live recordings from the Hammersmith Odeon and studio jam sessions, offering a deeper look into this important album.