The impact of The Last Don was considerable. At the time, it was one of the first reggaeton albums to achieve significant international projection, receiving 4 out of 5 stars from Jason Birchmeier of AllMusic. Initial sales were strong, exceeding 115,000 units in 2003, and by January 2005, over 250,000 copies had already been sold in the United States alone. Over time, the album achieved Gold and double Platinum certification in Latin America, and global sales figures soared, with up to 1 million copies reported worldwide, and even 2 million according to Billboard Italia, and 3 million by 2024. Beyond the numbers, The Last Don was recognized for its contribution to the genre.
Rolling Stone magazine included it in its list of the 100 best debut albums of all time at number 50, and Billboard noted it as an innovative work for reggaeton, similar to Barrio Fino. BMI also recognized Don Omar for this album, considering him one of the most successful Latin artists in crossovers. In 2026, Complex magazine named it the best reggaeton album in history, consolidating its legacy. A reissue under the The Gold Series series came out in 2006.