Among the most relevant songs are "Juke" and "My Babe", both of which reached the number one spot on the Billboard R&B singles chart. These tracks not only showcase Little Walter’s harmonica prowess but also capture the essence of the Chicago blues of the time. "Sad Hours" and "Blues with a Feeling" are other examples of his talent, both reaching second place on the same chart. The album’s production was overseen by key figures such as Leonard Chess, Phil Chess, and Willie Dixon, who helped shape this distinctive sound.
The impact of The Best of Little Walter has endured over the years, being reissued multiple times, though it has been surpassed in popularity by more extensive collections like Little Walter His Best: Chess 50th Anniversary Collection. In 1991, this album was inducted into the Blues Foundation Hall of Fame, and in 2003, it ranked 198 on Rolling Stone’s list of the "500 Greatest Albums of All Time". The album cover, featuring a black-and-white photograph of Little Walter holding his Hohner 64 Chromatic harmonica, adds a visual touch that complements his musical legacy.