Old Crow Medicine Show

The melody and chorus of "Wagon Wheel" come from a Dylan demo recorded during the sessions of Pat Garrett & Billy the Kid in 1973. Although it was never officially released, the song appeared on a bootleg recording that Critter Fuqua brought from London. Secor added verses to the song based on the original material. The album quickly reached number one on bluegrass charts and was certified platinum by the RIAA. Critter Fuqua left the band to deal with his alcohol addiction.With Rawlings once again as producer, they released Big Iron World two years later. This second album not only reached number one on bluegrass charts, but also entered the official album charts.

Don Was, another prominent producer, collaborated with them on their fifth album in five years, Tennessee Pusher. This work reached number 50 on the official charts and number 10 on country music charts. Later, the band took a break during which there were changes in their lineup; Critter Fuqua returned, and Chance McCoy, Cory Younts and Gill Landry joined, while Willie Watson left the group.The guitarist of Flogging Molly, Ted Hutt, produced their next album, Carry Me Back, released in 2012. With this new producer, folk influences intensified. The album reached number 22 on the Billboard 200, surpassing their previous works, and reached fourth place on country music charts, staying there for almost a year.

They also achieved their first number one on folk charts. That same year, they participated in the music documentary Big Easy Express by Emmett Malloy alongside Mumford & Sons and Edward Sharpe and the Magnetic Zeros. The film won a Grammy in 2013 for best music film. That year they were also inducted as members of the Grand Ole Opry.